T cell receptor signaling pathway
| PAG Title | T cell receptor signaling pathway |
| PAG ID | WIG000637 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells. |
| Species | Homo sapiens |
| nCoCo Score | 4,473 |
| Base PAG ID | WIG000637 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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